abstract：:Many observational studies and experimental and animal studies have demonstrated that estrogen therapy (ET) or hormone therapy (HT) significantly reduces the risk of coronary heart disease. Nonetheless, recent randomized controlled trials and the Nurses' Health Study in secondary prevention demonstrate trends toward a...

journal_title：Cardiovascular research

authors： Koh KK,Yoon BK

更新日期：2006-04-01 00:00:00

abstract：:Mayer waves are oscillations of arterial pressure occurring spontaneously in conscious subjects at a frequency lower than respiration (approximately 0.1 Hz in humans). Mayer waves are tightly coupled with synchronous oscillations of efferent sympathetic nervous activity and are almost invariably enhanced during states...

journal_title：Cardiovascular research

authors： Julien C

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVE:To determine if angiogenesis is altered in adult Endoglin heterozygous (Eng(+/-)) mice, the animal model for the vascular disorder hereditary hemorrhagic telangiectasia type 1 (HHT1). METHODS:Primary cultures of endothelial cells were generated from Eng(+/-) and Eng(+/+) mice and analyzed for proliferation, ...

journal_title：Cardiovascular research

authors： Jerkic M,Rodríguez-Barbero A,Prieto M,Toporsian M,Pericacho M,Rivas-Elena JV,Obreo J,Wang A,Pérez-Barriocanal F,Arévalo M,Bernabéu C,Letarte M,López-Novoa JM

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:In human heart failure beta-adrenergic-mediated protein kinase A (PKA) activity is down-regulated, while protein kinase C (PKC) activity is up-regulated. PKC-mediated myofilament protein phosphorylation might be detrimental for contractile function in cardiomyopathy. This study was designed to reveal the effe...

journal_title：Cardiovascular research

authors： van der Velden J,Narolska NA,Lamberts RR,Boontje NM,Borbély A,Zaremba R,Bronzwaer JG,Papp Z,Jaquet K,Paulus WJ,Stienen GJ

更新日期：2006-03-01 00:00:00

abstract：:The structural basis for the development of congestive heart failure (CHF) is a maladaptive myocardial remodeling process which occurs secondarily to post-myocardial infarction (MI), hypertensive hypertrophy, or cardiomyopathy. Both cellular and extracellular factors are involved in the remodeling process and it is th...

journal_title：Cardiovascular research

authors： Deschamps AM,Spinale FG

更新日期：2006-02-15 00:00:00

abstract：OBJECTIVE:Activation of peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma plays beneficial roles in cardiovascular disorders such as atherosclerosis and heart reperfusion. Although PPARalpha and gamma have been documented to reduce oxidative stress in the vasculature and the heart, the role of ...

journal_title：Cardiovascular research

authors： Pesant M,Sueur S,Dutartre P,Tallandier M,Grimaldi PA,Rochette L,Connat JL

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:The role of phosphorylation of the ryanodine receptor at serine-2808 (RyRS2808) in congestive heart failure (CHF) is controversial, and effects of RyRS2808 phosphorylation on contraction are unclear. It has been reported that diastolic sarcomere length (SL) fluctuations accompany propagating contractile waves...

journal_title：Cardiovascular research

authors： Obayashi M,Xiao B,Stuyvers BD,Davidoff AW,Mei J,Chen SR,ter Keurs HE

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Pericytes, located in close proximity to the underlying endothelium, form an integral component of the microvasculature. These cells are intimately involved in angiogenesis, which is of fundamental importance in many physiological and pathological processes. We evaluated the influence of pericyte-conditioned ...

journal_title：Cardiovascular research

authors： McIlroy M,O'Rourke M,McKeown SR,Hirst DG,Robson T

更新日期：2006-01-01 00:00:00

abstract：:The G protein-coupled receptor kinases (GRKs) participate with arrestins in the regulation and signal propagation of multiple G protein-coupled receptors (GPCR) of key physiological and pharmacological relevance in the cardiovascular system. The complex mechanisms of regulation of GRK expression, degradation and funct...

journal_title：Cardiovascular research

authors： Penela P,Murga C,Ribas C,Tutor AS,Peregrín S,Mayor F Jr

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Resistin belongs to a family of cysteine-rich secreted polypeptides that are mainly produced by monocytes/macrophages in humans. Recently, high concentrations of resistin were shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation. We examined if resistin was secreted f...

journal_title：Cardiovascular research

authors： Jung HS,Park KH,Cho YM,Chung SS,Cho HJ,Cho SY,Kim SJ,Kim SY,Lee HK,Park KS

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Dexamethasone-eluting stents are currently under evaluation to prevent post-angioplasty restenosis. The efficacy and safety of dexamethasone as an anti-restenotic agent is still unclear. We assess the effect of perivascular delivery of dexamethasone on vascular pathology in a mouse model of restenosis. METHO...

journal_title：Cardiovascular research

authors： Pires NM,Schepers A,van der Hoeven BL,de Vries MR,Boesten LS,Jukema JW,Quax PH

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:We have previously demonstrated that nuclear factor kappa B (NFkappaB) activation is needed for the development of cardiac hypertrophy in vivo. NFkappaB is a downstream transcription factor in the Toll-like receptor (TLR)-mediated signaling pathway; therefore, we investigated a role of TLR4 in cardiac hypertr...

journal_title：Cardiovascular research

authors： Ha T,Li Y,Hua F,Ma J,Gao X,Kelley J,Zhao A,Haddad GE,Williams DL,William Browder I,Kao RL,Li C

更新日期：2005-11-01 00:00:00

abstract：:Since the discovery of atrial natriuretic peptide (ANP) more than 20 years ago, numerous studies have focused on the mechanisms regulating ANP secretion. From a physiological standpoint, the most important factor governing ANP secretion is mechanical stretching of the atria, which normally occurs when extracellular fl...

journal_title：Cardiovascular research

authors： Dietz JR

更新日期：2005-10-01 00:00:00

abstract：:Ischemia-reperfusion of the heart and other organs results in the accumulation of unesterified arachidonic acid (AA) via the action of membrane-bound phospholipases, primarily phospholipase A2. AA can be metabolized by the classical cyclooxygenase (COX) and lipoxygenase (LOX) pathways to well-characterized metabolites...

journal_title：Cardiovascular research

authors： Gross GJ,Falck JR,Gross ER,Isbell M,Moore J,Nithipatikom K

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:Cardiac parasympathetic nerve activity is reduced in most cardiovascular disease states, and this may contribute to enhanced cardiac sympathetic responsiveness. Disruption of inhibitory G-proteins (Gi) ablates the cholinergic pathway and increases cardiac endothelial nitric oxide (NO) synthase (eNOS) expressi...

journal_title：Cardiovascular research

authors： Danson EJ,Zhang YH,Sears CE,Edwards AR,Casadei B,Paterson DJ

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:Heart failure is associated with reduced function of sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) but increased function of sarcolemmal Na+/Ca2+ exchanger (NCX), leading to decreased SR Ca2+ content and loss of frequency-potentiation of contractile force. We reported that SERCA2a-overexpression in transg...

journal_title：Cardiovascular research

authors： Maier LS,Wahl-Schott C,Horn W,Weichert S,Pagel C,Wagner S,Dybkova N,Müller OJ,Näbauer M,Franz WM,Pieske B

更新日期：2005-09-01 00:00:00

abstract：:Having an apparently healthy, thriving infant fail to reach his/her first birthday is profoundly tragic. This tragedy is compounded when the infant's death is unexpected and unexplained, signed out as sudden infant death syndrome (SIDS). Despite impressive success and welcome reductions in these tragic deaths due in l...

journal_title：Cardiovascular research

authors： Tester DJ,Ackerman MJ

更新日期：2005-08-15 00:00:00

abstract：:The last decade has seen a dramatic increase in the understanding of the molecular basis of arrhythmias. Much of this new information has been driven by genetic studies that focused on rare, monogenic arrhythmia syndromes that were accompanied or followed by cellular electrophysiological or biochemical studies. The ma...

journal_title：Cardiovascular research

authors： Kääb S,Schulze-Bahr E

更新日期：2005-08-15 00:00:00

abstract：OBJECTIVE:Hereditary long QT syndrome (LQTS) is a genetically heterogeneous disease characterized by prolonged QT intervals and an increased risk for ventricular arrhythmias and sudden cardiac death. Mutations in the voltage-gated potassium channel subunit KCNQ1 induce the most common form of LQTS. KCNQ1 is associated ...

journal_title：Cardiovascular research

authors： Thomas D,Wimmer AB,Karle CA,Licka M,Alter M,Khalil M,Ulmer HE,Kathöfer S,Kiehn J,Katus HA,Schoels W,Koenen M,Zehelein J

更新日期：2005-08-15 00:00:00

abstract：OBJECTIVE:Although aldosterone has been implicated in the pathogenesis of cardiac hypertrophy and heart failure, its cellular mechanism of action on cardiomyocyte function is not yet completely elucidated. This study was designed to investigate the effect of aldosterone on calcium channel expression and cardiomyocyte c...

journal_title：Cardiovascular research

authors： Lalevée N,Rebsamen MC,Barrère-Lemaire S,Perrier E,Nargeot J,Bénitah JP,Rossier MF

更新日期：2005-08-01 00:00:00

abstract：:Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-gamma (IFN-gamma) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-gamma regulates the...

journal_title：Cardiovascular research

authors： Harvey EJ,Ramji DP

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:While atrial natriuretic peptide (ANP) has been shown to be released mainly from cardiac muscle cells in response to atrial distension, the regulatory mechanisms of ANP secretion are still not fully understood. We sought to determine whether the ATP-sensitive K+ (K(ATP)) channel modulates the secretion of ANP...

journal_title：Cardiovascular research

authors： Saegusa N,Sato T,Saito T,Tamagawa M,Komuro I,Nakaya H

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Current guidelines are controversial regarding exercise intensity in cardiovascular prevention and rehabilitation. Although high-intensity training induces larger increases in fitness and maximal oxygen uptake (VO(2max)), moderate intensity is often recommended as equally effective. Controlled preclinical stu...

journal_title：Cardiovascular research

authors： Kemi OJ,Haram PM,Loennechen JP,Osnes JB,Skomedal T,Wisløff U,Ellingsen Ø

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Experimental evidence suggests that modulation of myocardial substrate metabolism can markedly affect the progression of chronic heart failure (HF). We tested whether the inhibition of carnitine palmitoyl transferase-I (CPT-I), the enzyme regulating mitochondrial fatty acid oxidation, slows left ventricular r...

journal_title：Cardiovascular research

authors： Lionetti V,Linke A,Chandler MP,Young ME,Penn MS,Gupte S,d'Agostino C,Hintze TH,Stanley WC,Recchia FA

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:We tested the hypothesis that simultaneous inhibition of the endothelial integrin alpha(v)beta(3) and the platelet glycoprotein IIb/IIIa receptor will substantially reduce infarct size in a model of acute coronary thrombosis and primary angioplasty. METHODS:Dogs were subjected to thrombus formation in the le...

journal_title：Cardiovascular research

authors： Sakuma T,Sari I,Goodman CN,Lindner JR,Klibanov AL,Kaul S

更新日期：2005-06-01 00:00:00

abstract：:Although the level and pace of population aging display high geographical variability, virtually all countries have been experiencing growth in their elderly population, particularly in developed nations. Because aging is a major risk factor for atherosclerosis and associated disease, it is of up most importance to un...

journal_title：Cardiovascular research

authors： Edo MD,Andrés V

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:Diastolic dysfunction is a characteristic finding of the aged mammalian heart. Parvalbumin acts as a Ca2+ sink and enhances relaxation in skeletal muscle, and overexpression of parvalbumin in myocardium increased cardiac relaxation in vitro as well as in vivo. Therefore, the objective of this study is to test...

journal_title：Cardiovascular research

authors： Schmidt U,Zhu X,Lebeche D,Huq F,Guerrero JL,Hajjar RJ

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of aging on left ventricular (LV) geometry, collagen levels, matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) abundance, and myocardial fibroblast function. METHODS:Young (3-month-old; n=28), middle-aged (MA; 15-month-old; n=17), and old (23-month-old; n...

journal_title：Cardiovascular research

authors： Lindsey ML,Goshorn DK,Squires CE,Escobar GP,Hendrick JW,Mingoia JT,Sweterlitsch SE,Spinale FG

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:It was our aim to investigate effects of human LDL, copper-, or AAPH-oxidized over different periods of time to different degrees (ox-LDL), on viability and electrophysiological parameters of isolated ventricular myocytes of guinea pigs. METHODS:Guinea pig ventricular myocytes were incubated with ox-LDL or n...

journal_title：Cardiovascular research

authors： Zorn-Pauly K,Schaffer P,Pelzmann B,Bernhart E,Wei G,Lang P,Ledinski G,Greilberger J,Koidl B,Jürgens G

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:Evidence suggests important relationships among chronic inflammatory processes, endothelial dysfunction, hypertension and target organ damage. The present study examined the effects of chronic treatment with an anti-inflammatory p38 mitogen-activated protein kinase (MAPK) inhibitor (SB-239063AN) in the N(omeg...

journal_title：Cardiovascular research

authors： Olzinski AR,McCafferty TA,Zhao SQ,Behm DJ,Eybye ME,Maniscalco K,Bentley R,Frazier KS,Milliner CM,Mirabile RC,Coatney RW,Willette RN

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:To examine if adenosine prevents oxidant-induced mitochondrial dysfunction by producing nitric oxide (NO) in cardiomyocytes. METHODS AND RESULTS:Adenosine significantly enhanced the fluorescence of DAF-FM, a dye specific for NO, implying that adenosine induces synthesis of NO. Adenosine-induced NO production...

journal_title：Cardiovascular research

authors： Xu Z,Park SS,Mueller RA,Bagnell RC,Patterson C,Boysen PG

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:Oxidized low-density lipoprotein (ox-LDL) increases superoxide anion (O(2)(-)) production by the endothelial nitric oxide (NO) synthase (eNOS). We assessed whether the uncoupling of eNOS was associated with alterations in eNOS phosphorylation and/or the assembly of the eNOS signaling complex. METHODS AND RES...

journal_title：Cardiovascular research

authors： Fleming I,Mohamed A,Galle J,Turchanowa L,Brandes RP,Fisslthaler B,Busse R

更新日期：2005-03-01 00:00:00

abstract：:Therapeutic neovascularization for cardiovascular ischemia is a promising avenue in spite of disappointing early clinical trial results. The concept of three different mechanisms of neovascularization has served to define potential therapeutic targets such as vascular remodeling and stem cell recruitment, but it is an...

journal_title：Cardiovascular research

authors： Cao Y,Hong A,Schulten H,Post MJ

更新日期：2005-02-15 00:00:00

abstract：OBJECTIVE:Induction of angiogenesis has been reported subsequent to eNOS overexpression or activation, the latter involving Hsp90 as a chaperone protein. Here, we investigated the potential of regional Hsp90 overexpression to induce therapeutic neovascularization in vivo in a chronic rabbit hindlimb ischemia model. ME...

journal_title：Cardiovascular research

authors： Pfosser A,Thalgott M,Büttner K,Brouet A,Feron O,Boekstegers P,Kupatt C

更新日期：2005-02-15 00:00:00

abstract：:Mouse models have been frequently used in the study of Chlamydia pneumoniae (also known as Chlamydophila pneumoniae) infections. This gram-negative obligate intracellular bacterium causes respiratory infections, followed by dissemination of the bacterium to various organs throughout the body, including cardiovascular ...

journal_title：Cardiovascular research

authors： de Kruif MD,van Gorp EC,Keller TT,Ossewaarde JM,ten Cate H

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:Defects in myocardial mitochondrial structure and function have been associated with heart failure in humans and animal models. Mice lacking the muscle LIM protein (MLP) develop morphological and clinical signs resembling human dilated cardiomyopathy and heart failure. We tested the hypothesis that defects in...

journal_title：Cardiovascular research

authors： van den Bosch BJ,van den Burg CM,Schoonderwoerd K,Lindsey PJ,Scholte HR,de Coo RF,van Rooij E,Rockman HA,Doevendans PA,Smeets HJ

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:To examine whether altered PCO2 or HCO3- at normal pH potentiate agonist-induced vasoconstriction of small pulmonary arteries, and if so to determine the mechanism. METHODS:Small intrapulmonary arteries (IPA) from rats were mounted on a myograph and PGF2alpha (3 microM)-induced tension recorded before and 40...

journal_title：Cardiovascular research

authors： Vanková M,Snetkov VA,Knock GA,Aaronson PI,Ward JP

更新日期：2005-02-01 00:00:00

abstract：:Oxygen-derived free radicals are thought to contribute to the initiation and progression of cardiovascular disease via several different mechanisms, such as consumption of nitric oxide, oxidation of proteins and lipids, and activation of redox-sensitive signalling cascades. Vascular NADPH oxidases are important source...

journal_title：Cardiovascular research

authors： Brandes RP,Kreuzer J

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The K(+) channel encoded by the human ether-a-go-go-related gene (HERG) is crucial for repolarization in the human heart. In order to investigate the impact of HERG current (I(Kr)) on the incidence of cardiac arrhythmias, we generated a transgenic mouse expressing HERG specifically in the heart. METHODS AND ...

journal_title：Cardiovascular research

authors： Royer A,Demolombe S,El Harchi A,Le Quang K,Piron J,Toumaniantz G,Mazurais D,Bellocq C,Lande G,Terrenoire C,Motoike HK,Chevallier JC,Loussouarn G,Clancy CE,Escande D,Charpentier F

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Cardiac energetics and performance depend on the expression level of the fast (alpha-) and slow (beta-) myosin heavy chain (MHC) isoform. In ventricular tissue, the beta-MHC isoform predominates, whereas in atrial tissue a variable mixture of alpha- and beta-MHC is found. In several cardiac diseases, the slow...

journal_title：Cardiovascular research

authors： Narolska NA,van Loon RB,Boontje NM,Zaremba R,Penas SE,Russell J,Spiegelenberg SR,Huybregts MA,Visser FC,de Jong JW,van der Velden J,Stienen GJ

更新日期：2005-01-01 00:00:00